解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. De...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17080440
更新日期:2019-07-26 00:00:00
abstract::Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17070425
更新日期:2019-07-20 00:00:00
abstract::Several known sesquiterpenoid quinones and quinols (1-9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongiaelegans. The planar structure of 10 was determined from spectroscopic analyses, and its relative and a...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17070423
更新日期:2019-07-19 00:00:00
abstract::Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the pla...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17070418
更新日期:2019-07-19 00:00:00
abstract::Death-associated protein kinase 1 (DAPK1) expression induced by diverse death stimuli mediates apoptotic activity in various cancers, including ovarian cancer. In addition, mutual interaction between the tumor suppressor p53 and DAPK1 influences survival and death in several cancer cell lines. However, the exact role ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17070412
更新日期:2019-07-12 00:00:00
abstract::Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (Th) cells to the site of infection and distinct patterns of cytokine production....
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17070382
更新日期:2019-06-26 00:00:00
abstract::In our current investigation, we evaluated the effect of Chlorella pyrenoidosa protein hydrolysate (CPPH) and Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) on calcium absorption and gut microbiota composition, as well as their in vivo regulatory mechanism in SD rats fed low-calcium diets. Potent ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060348
更新日期:2019-06-11 00:00:00
abstract::Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060347
更新日期:2019-06-11 00:00:00
abstract::Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060344
更新日期:2019-06-10 00:00:00
abstract::Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060332
更新日期:2019-06-03 00:00:00
abstract::Ovarian cancer is one of the prevalent gynecological cancers occurring in women. In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue. To assist standard anti-cancer agents in the cure of ovarian cancer, development and application of new compounds such as s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060331
更新日期:2019-06-03 00:00:00
abstract::The role of the marine environment in the development of anticancer drugs has been widely reviewed, particularly in recent years. However, the innovation in terms of clinical benefits has not been duly emphasized, although there are important breakthroughs associated with the use of marine-derived anticancer agents th...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17060329
更新日期:2019-06-02 00:00:00
abstract::Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products that they synthesize, support cyanobacterial success in colonization of their respective ec...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17060320
更新日期:2019-05-30 00:00:00
abstract::So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first chemical investigation of the sponge Narrabeena nigra collected around the Futuna Islands yielded 18 ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060319
更新日期:2019-05-30 00:00:00
abstract::Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050307
更新日期:2019-05-24 00:00:00
abstract::Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050299
更新日期:2019-05-20 00:00:00
abstract::The secondary metabolite Tyrian purple, also known as shellfish purple and royal purple, is a dye with historical importance for humans. The biosynthetic origin of Tyrian purple in Muricidae molluscs is not currently known. A possible role for symbiotic bacteria in the production of tyrindoxyl sulphate, the precursor ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050264
更新日期:2019-05-03 00:00:00
abstract::PT-peptide is derived from the anti-lipopolysaccharide factor of the swimming crab Portunus trituberculatus. The peptide, consisting of 34 amino acids, contains a lipopolysaccharide binding domain. In this study, we investigated the effect of PT-peptide encapsulated in raw milk-derived extracellular vesicles (EVs), de...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050248
更新日期:2019-04-26 00:00:00
abstract::In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17040234
更新日期:2019-04-19 00:00:00
abstract::Spirotetronates are actinomyces-derived polyketides that possess complex structures and exhibit potent and unexplored bioactivities. Due to their anticancer and antimicrobial properties, they have potential as drug hits and deserve further study. In particular, abyssomicin C and tetrocarcin A have shown significant pr...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17040232
更新日期:2019-04-19 00:00:00
abstract::The first total synthesis of the marine nucleoside Mycalisine B-a naturally occurring and structurally distinct 4,5-unsaturated 7-deazapurine nucleoside-has been accomplished in 10 linear steps with 27.5% overall yield from commercially available 1,2,3,5-tetra-O-acetyl-ribose and tetracyanoethylene. Key steps of the a...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17040226
更新日期:2019-04-14 00:00:00
abstract::The venom of each Conus species consists of a diverse array of neurophysiologically active peptides, which are mostly unique to the examined species. In this study, we performed high-throughput transcriptome sequencing to extract and analyze putative conotoxin transcripts from the venom ducts of 3 vermivorous cone sna...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030193
更新日期:2019-03-26 00:00:00
abstract::Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions-(1) as light harvesting molecules-primary carotenoids, and (2) as antioxidants, acting against reactive oxygen species⁻secondary carotenoids. Because of their strong antioxidant properti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030187
更新日期:2019-03-22 00:00:00
abstract::Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030186
更新日期:2019-03-21 00:00:00
abstract::Chondroitinase (ChSase), a type of glycosaminoglycan (GAG) lyase, can degrade chondroitin sulfate (CS) to unsaturate oligosaccharides, with various functional activities. In this study, ChSase AC II from a newly isolated marine bacterium Arthrobacter sp. CS01 was cloned, expressed in Pichia pastoris X33, purified, and...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030185
更新日期:2019-03-20 00:00:00
abstract::Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17030170
更新日期:2019-03-16 00:00:00
abstract::The marine alga, Symphyocladia latiuscula (Harvey) Yamada, is a good source of bromophenols with numerous biological activities. This study aims to characterize the anti-diabetic potential of 2,3,6-tribromo-4,5-dihydroxybenzyl derivatives isolated from S. latiuscula via their inhibition of tyrosine phosphatase 1B (PTP...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030166
更新日期:2019-03-14 00:00:00
abstract::The aim of the present work was to load a Hibiscus sabdariffa (HS) hydroalcoholic extract into in situ gelling formulations for the treatment of oral mucositis and esophagitis. Such formulations, selected as the most promising options in a previous work of ours, were composed by κ-carrageenan (κ-CG), a sulfated marine...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030153
更新日期:2019-03-05 00:00:00
abstract::Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030144
更新日期:2019-03-01 00:00:00
abstract::In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis. Because of their structural similarity with HS, sulfa...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030140
更新日期:2019-02-27 00:00:00
abstract::Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030138
更新日期:2019-02-27 00:00:00
abstract::Astaxanthin (AXT), a xanthophyll carotenoid compound, has potent antioxidant, anti-inflammatory and neuroprotective properties. Neuroinflammation and oxidative stress are significant in the pathogenesis and development of Alzheimer's disease (AD). Here, we studied whether AXT could alleviate neuroinflammation, oxidati...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020123
更新日期:2019-02-18 00:00:00
abstract::Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020115
更新日期:2019-02-12 00:00:00
abstract::Green seaweeds are rich sources of sulfated polysaccharides (SPs) with potential biomedical and nutraceutical applications. The aim of this work was to evaluate the immunostimulatory activity of SPs from the seaweed, Caulerpa cupressoides var. flabellata on murine RAW 264.7 macrophages. SPs were evaluated for their ab...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020105
更新日期:2019-02-09 00:00:00
abstract::In this study, as part of our continuous search for environmentally-friendly antifoulants from natural resources, subergorgic acid (SA) was identified from the gorgonian coral Subergorgia suberosa, demonstrating non-toxic, significant inhibitory effects (EC50 1.25 μg/mL, LC50 > 25 μg/mL) against the settlement of Bala...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020101
更新日期:2019-02-06 00:00:00
abstract::A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020100
更新日期:2019-02-06 00:00:00
abstract::The red macroalga Agarophyton chilensis is a well-known producer of eicosanoids such as hydroxyeicosatetraenoic acids, but the alga produces almost no prostaglandins, unlike the closely related A. vermiculophyllum. This indicates that the related two algae would have different enzyme systems or substrate composition. ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020096
更新日期:2019-02-02 00:00:00
abstract::The skin, the largest organ in humans, is exposed to major sources of outdoor air pollution, such as fine particulate matter with a diameter ≤ 2.5 µm (PM2.5). Diphlorethohydroxycarmalol (DPHC), a marine-based compound, possesses multiple activities including antioxidant effects. In the present study, we evaluated the ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020095
更新日期:2019-02-01 00:00:00
abstract::A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber Paelopatides sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH v...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020084
更新日期:2019-02-01 00:00:00
abstract::The red seaweed Pyropia yezoensis is an ideal research model for dissecting the molecular mechanisms underlying its robust acclimation to abiotic stresses in intertidal zones. Glycine betaine (GB) was an important osmolyte in maintaining osmotic balance and stabilizing the quaternary structure of complex proteins unde...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010070
更新日期:2019-01-21 00:00:00